March 6, 2026
Health Optimization

Micronutrient Testing:  What You Should Know

4
MINUTES

Today we live in a society of OVEReating and UNDERnourishment. It’s estimated 1 in 3 Americans are deficient in at least 10 key minerals. Those numbers are no surprise given an increase in processed foods and nutrient poor soil. What’s worse is there is no routine testing performed to identify your levels.

Blood testing provides a powerful tool to improve your mental and physical performance, reduce your future risk of chronic disease, and increase your longevity. It is well known that blood tests are used to diagnose disease — but blood work is most powerful when used to monitor your health in a more proactive way.

Blood tests allow you to take an inside look at your body and how it functions. Getting regular blood work is the closest thing we have to x-ray vision to see inside the body. Understanding your blood biomarkers — the molecular signs of health — will help you make more informed decisions about your diet, lifestyle, fitness, and supplement choices.

Extracellular vs. Intracellular Testing

Serum testing is a simple lab test that determines what is in the liquid part of your blood. It tests what is floating or passing through your body in that moment of time and is measured outside of the cells (extracellular). 

Alternatively, a test that measures inside your red and white blood cells (intracellular) would be the most adequate way to measure because it looks at the nutrient status inside.

Extracellular can be misleading as it doesn’t truly indicate what your body is absorbing at a cellular level/functional need. Metabolism, protein synthesis, hormone production and detoxification all occur inside. Therefore, measuring the outside cells tells you nothing about these important functions! Imagine this scenario, you’re dehydrated and desperately thirsty. You jump into a pool but don’t drink the water. What happens to your thirst? Nothing. Because you didn’t drink the water, it didn’t make its way into your body. Just like the pool water and dehydration, your body could potentially be denied of essential vitamins and nutrients because they aren’t making their way into your cells even if your serum results show they are surrounded by the cell itself.

A common example of the powerful difference between results with extracellular (serum) vs. intracellular is a B12 deficiency. Your serum test results come back within normal reference range, but you're still feeling symptoms of chronic fatigue. You seek out an intracellular test to see if your cells are truly absorbing B12. You may discover that you’re not only low or deficient, but that it’s also the case for all your B vitamins! B1, B2, B3, B5, B6, B12 and folate are all cofactors necessary for converting food into energy. Unfortunately, you won't make this essential discovery through just a serum test. Serum levels often fall in the normal range when a true intracellular deficiency exists. Deficiency of a nutrient can cause cellular disruption. If your cells aren’t functioning, your body isn’t either! Additionally, serum tests can be transient, meaning it fluctuates greatly and your results may not always be truly accurate. The lifespan of cells tested in intracellular testing are about 4-6 months, so it displays your nutrient status over a period of months, not days or hours.

Why is serum testing so commonly used?

It's widely available, easy to perform, inexpensive and the way it's been done for decades. Reference ranges are well understood and easy for your doctor to check or uncheck a box for your results. The truth is that intracellular testing is much more clinically informative. Not only will you know what your body needs to function properly, you'll also obtain valuable information on how to best boost your levels. Often based on the results of your test, people may be able to supplement some of what their body needs through dietary and lifestyle changes.

Who should test?

Everyone is a good candidate for intracellular testing! Whether or not you have symptoms, it’s still beneficial to know what your body needs. There are a number of chronic conditions caused by micronutrient deficiencies including migraines, fatigue, autism, inflammation, osteoporosis and mood disorders. The amount of each nutrient you need varies from person to person and depends on genetics, age, overall health, pregnancy/breastfeeding, and the amount of physical activity you do at what intensity level. It’s important to understand that even though you may be consuming an adequate diet, your intake levels may not be sufficient and still provide risks for deficiencies and the disorders associated with them. So, if you don’t eat a wide range of foods in your diet, you’re especially a good candidate for testing!

How do I get tested?

For more information on Intracellular (Micronutrient) testing contact 618.632.9000 (O’Fallon, IL) or 314.833.9000 (Town and Country, MO).

Resources:

Click here

Related Resources

January 26, 2026

Research Use Only Peptides: Why the FDA Is Ending the RUO Era

Health Optimization
January 13, 2026

TB006 for Alzheimer’s: What We Know So Far About This Galectin-3 Therapy

Health Optimization
November 25, 2025

Do I Need Liver Supplements? Here’s What to Know

Health Optimization
October 28, 2025

How to Increase Sperm Count: 7 Ways to Boost Male Fertility

Health Optimization
October 28, 2025

Best Nitric Oxide Foods for Better Blood Flow & Sexual Health

Health Optimization
October 28, 2025

Thyroid Problems in Men: Symptoms to Watch For & What to Do

Health Optimization
October 6, 2025

Vitamin B12: How Much Per Day Should You Take?

Health Optimization
October 5, 2025

Iron Deficiency Symptoms to Watch For

Health Optimization
October 5, 2025

Magnesium Glycinate vs. Magnesium Citrate: Which is Better?

Health Optimization
October 5, 2025

Vitamin D3 and K2: Why You Should Take Them Together

Health Optimization
September 24, 2025

Prebiotic vs. Probiotic Supplements for Gut Health: What’s the Difference?

Health Optimization
September 16, 2025

Do Supplements for Muscle Building Work? What We Tell Our Patients

Health Optimization
August 29, 2025

Insulin Resistance Symptoms (& How To Fix It)

Health Optimization
August 29, 2025

What Is Carrageenan and Is It Dangerous?

Health Optimization
August 29, 2025

Creatine Benefits for Men (Beyond Muscle Growth)

Health Optimization
June 25, 2025

Melatonin for Sleeping: Why it’s Not Working & How to Fix It

Health Optimization
June 13, 2025

Male Birth Control: What to Know About ‘The Pill’ for Men

Health Optimization
June 13, 2025

Prostate Cancer Symptoms: What Joe Biden’s Diagnosis Means for Men Over 40

Health Optimization
June 3, 2025

What is PEMF Therapy? Everything You Need to Know

Health Optimization
June 13, 2025

Brain Peptides: Can They Actually Boost Cognitive Function?

Health Optimization
June 3, 2025

TMG Supplements: Why Biohackers Can’t Get Enough

Health Optimization
May 14, 2025

MTHFR Gene Mutation Symptoms: What Your Lab Work Isn't Telling You

Health Optimization
May 14, 2025

The Best Health Screenings for Men (& When to Get Them)

Health Optimization
May 14, 2025

Methylated Multivitamins: Should You Make the Switch?

Health Optimization
April 23, 2025

Hydrogen Water: What to Know About the Biohack Gary Brecka Swears By

Health Optimization
April 22, 2025

Telomere Testing: Can You Reverse Your Biological Age?

Health Optimization
April 22, 2025

Men & Progesterone: Why You Should Avoid This Hormone Like the Plague

Health Optimization
March 19, 2025

The Best Anti-Aging Supplements For Men

Health Optimization
March 13, 2025

NAD: Side Effects & Benefits No One Is Talking About

Health Optimization
December 29, 2024

Can Hormone Replacement Therapy Increase Cancer Risk?

Health Optimization
December 29, 2024

Sperm Testing for Men: What to Know & Where to Go

Health Optimization
December 10, 2024

Hormone Replacement Therapy for Men vs. Women

Health Optimization
December 10, 2024

Low Progesterone Symptoms in Women (& What To Do About It)

Health Optimization
December 2, 2024

Tirzepatide for Weight Loss: How Does It Work?

Health Optimization
December 2, 2024

PT-141 for Men: Is it Better Than Viagra?

Health Optimization
December 2, 2024

Coconut Oil as Lube: Here’s Why You Should Avoid It

Health Optimization
December 2, 2024

Are Peptides FDA-approved?

Health Optimization
December 2, 2024

Why You Should Reconsider Using PPI Drugs Long-Term

Health Optimization
December 2, 2024

Statins vs. Estradiol: Which is Better for Heart Health?

Health Optimization
November 12, 2024

Post-Finasteride Syndrome: What You Need to Know

Health Optimization
October 29, 2024

Can Lack of Sleep Lower Testosterone?

Health Optimization
October 29, 2024

Methylation Testing 101: Is it the Key to Healthy Aging?

Health Optimization
October 29, 2024

Red Light Therapy for Pain Relief

Health Optimization
October 8, 2024

What Are Food Sensitivity Tests and How Do They Work?

Health Optimization
August 8, 2024

Insulin Resistance & PCOS Symptoms: The Labs You Should Request with Angie Nichols

Health Optimization
August 8, 2024

How to Make Semaglutide Work Better & Faster

Health Optimization
August 8, 2024

Creatine For Women: Here’s What To Know

Health Optimization
August 8, 2024

6 Symptoms of Low Nitric Oxide | Symptoms To Watch For

Health Optimization
July 22, 2024

“Am I At Risk For A Heart Attack?!” How We Screen Patients in 2024

Health Optimization
July 19, 2024

How to Last Longer in Bed: 10 Proven Tips from Men's Health Experts

Health Optimization
July 16, 2024

Ketamine Therapy: Are The Side Effects Worth It?

Health Optimization
August 5, 2024

Micronutrient Testing: What Your Results Actually Mean

Health Optimization
March 27, 2025

What is Sermorelin? Let's Talk Risks & Benefits for Men

Health Optimization
February 29, 2024

Does A Myer's Cocktail Actually Work? Here's What We've Seen.

Health Optimization
February 29, 2024

Male Fertility Tests | What's Next For Male Fertility?

Health Optimization
February 29, 2024

Is A Healthy Gut the Key to Weight and Blood Sugar Control?

Health Optimization
January 1, 1970

Is A Healthy Gut the Key to Weight and Blood Sugar Control?

Health Optimization
January 29, 2024

Can You Actually Lower Your Cortisol Levels? | What We Know (& What To Take)

Health Optimization
April 17, 2023

Light: The missing piece of the wellness puzzle

Health Optimization
July 4, 2022

You Don't Need To Be Sick To Get An IV!

Health Optimization
June 30, 2022

Endocrine Disruptors: The Frightening Truth

Health Optimization
June 23, 2022

Nitric Oxide for Men’s Health: Insights from Dr. Nathan Bryan & Amy Stuttle

Health Optimization
October 27, 2021

What Is BPH? Understanding Enlarged Prostate & How to Fix It

Health Optimization
August 16, 2021

Sex on a Screen: Free Adult Entertainment Comes with a Cost

Health Optimization
June 22, 2021

You Are What You Eat & You Will Want to Eat More of this Fat!

Health Optimization
August 4, 2025

Glutathione Benefits for Men: The Antioxidant You’re Probably Missing

Health Optimization
June 2, 2025

How to Sleep Better: 7 Strategies for Deeper Sleep

Health Optimization
January 22, 2021

Supplements for Men’s Health: Medical-Grade vs. Over-the-Counter

Health Optimization
November 23, 2020

Why You Should Worry About The Fat You Can't See

Health Optimization
April 8, 2025

Nitric Oxide Benefits for Men: Boost Energy, Circulation, & Sexual Health

Health Optimization
May 29, 2020

What is the Difference Between Lean Body Mass and Muscle Mass?

Health Optimization
April 16, 2025

Cortisol Levels Explained: How to Lower Cortisol for Better Health

Health Optimization
June 2, 2025

Vitamin D for Men: Are You Getting Enough of the Sunshine Vitamin?

Health Optimization
February 6, 2019

Understanding Human Chorionic Gonadotropin (HCG)

Health Optimization
July 10, 2025

Sermorelin Therapy: A Smarter Approach to HGH Restoration

Health Optimization
February 11, 2018

Tony La Russa Endorses Local Business Victory Men's Health

Health Optimization

Ready to start feeling better than ever?

Get Started